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Evolution of the mannose-binding lectin gene in primates

✍ Scribed by Verga Falzacappa, M V; Segat, L; Puppini, B; Amoroso, A; Crovella, S


Book ID
110037653
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
116 KB
Volume
5
Category
Article
ISSN
1466-4879

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Mannose-binding lectin (MBL) is a C-type lectin produced mainly by the liver that binds to a wide range of pathogens. Polymorphisms at the promoter and exon 1 of the MBL2 gene are responsible for low serum levels of MBL and have been associated with an increased risk of infections. We prospectively