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Evolution of the IL-6/class IB cytokine receptor family in the immune and nervous systems

✍ Scribed by T. Yamamori; A. Sarai

Book ID
113401568
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
559 KB
Volume
88
Category
Article
ISSN
0928-4257

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The family of the IL-6-Type cytokines: S
The family of the IL-6-Type cytokines: Specificity and promiscuity of the receptor complexes
✍ Joachim Grotzinger; GΓΌnther Kurapkat; Axel Wollmer; Michael Kalai; Stefan Rose-J πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 510 KB

The cytokines IL-6, LIF, CNTF, OSM, IL-11, and CT-1 have been grouped into the family of IL-6-type cytokines, since they all require gp130 for signal transduction. Interestingly, gp130 binds directly to OSM, whereas complex formation with the other cytokines depends on additional receptor subunits.