𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Evolution of the Concept of Synthesis Strategy in the COSYMA System: Introduction of the Synthesis Invariant

✍ Scribed by Ellermann, Luc ;Jauffret, Philippe ;Ostermann, Claude ;Kaufmann, Gérard

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
450 KB
Volume
1997
Category
Article
ISSN
0947-3440

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

COSYMA is a program for the computer‐assisted design of organic synthesis; its aim is to propose strategies for the synthesis of given compounds. These strategies are automatically learnt from global syntheses described in the literature, and adapted to the specifics of the target molecule. This paper describes an evolution of the formalization of synthesis strategy by taking into account untouched fragments, and the resulting improvement of the COSYMA program.

📜 SIMILAR VOLUMES

The Evolution of the Concept of Isotonic
The Evolution of the Concept of Isotonicity in Pharmacy
✍ Szekely, Ivan J. ;Goyan, Frank M. 📂 Article 📅 1952 🏛 Elsevier ⚖ 221 KB

The concept of isotonicity in pharmacy arose at the turn of the century from earlier fundamental discoveries. Various approaches to the problem of determining quantities of substances required for the preparation of isotonic solutions that were adopted by pharmacists are discussed in the light of pr

The evolution of the concept of medicali
The evolution of the concept of medicalization in the late twentieth century
✍ Robert A. Nye 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 91 KB

## Abstract This article attempts to outline a history of the critique of medicalization that developed in the 1960s in the work of Thomas Szasz, R. D. Laing, Michael Foucault, and others that was applied in their work to medical and psychiatric theory and practice, the penal system, and public hea