EVOLUTION OF THE ATP-BINDING CASSETTE (ABC) TRANSPORTER SUPERFAMILY IN VERTEBRATES*
β Scribed by Dean, Michael; Annilo, Tarmo
- Book ID
- 111918464
- Publisher
- Annual Reviews
- Year
- 2005
- Tongue
- English
- Weight
- 386 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1527-8204
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## Abstract The phenomenon of multidrug resistance (MDR) in various malignant neoplasms has been reported as being caused by one or multiple expressions of ATPβbinding cassette (ABC) superfamily protein, including Pβglycoprotein/multidrug resistance (MDR) 1 and the MDR protein (MRP) family. However
Interindividual variability in hepatic canalicular transporter expression might predispose to the development of hepatic disorders such as acquired forms of intrahepatic cholestasis. We therefore investigated expression patterns of bile salt export pump (BSEP, ABCB11), multidrug resistance protein 3