𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Evolution of the androgen receptor: structure–function implications

✍ Scribed by Joseph W. Thornton; Darcy B. Kelley

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
229 KB
Volume
20
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

✦ Synopsis

To shed light on the nature and evolution of structure-function relations in the androgen receptor (AR), we have undertaken a comparative analysis of all available AR and other steroid receptor sequences. We have identified a group of amino acids that "diagnose" the clade of androgen receptors--residues that are strictly conserved among the ARs but not shared with other receptors. We hypothesize that these amino acids, clustered in a few regions of the protein, confer upon the androgen receptor its unique functions, including recognition of specific DNA response elements and affinity for androgens, rather than other steroid hormones. The four domains of the AR display markedly different rates of evolutionary divergence; conserved portions of the sequence, including small stable stretches within otherwise divergent regions, may be essential to receptor function. Current data from experimental, crystallographic, and clinical studies support these hypotheses, which can now be further tested in the laboratory.

📜 SIMILAR VOLUMES

Expression, structure, and function of a
Expression, structure, and function of androgen receptor in advanced prostatic carcinoma
✍ Culig, Zoran; Hobisch, Alfred; Hittmair, Anton; Peterziel, Heike; Cato, Andrew C 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 53 KB 👁 2 views

## BACKGROUND. Endocrine therapy for prostate cancer aims to reduce the levels of circulating androgen or to inhibit androgen action by blocking the androgen receptor in the prostate, or both. Studies in various animal and human prostate cancer models suggested that there may be a downregulation o

The evolution of the purchasing function
The evolution of the purchasing function
✍ R. McIvor; P. Humphreys; E. McAleer 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB 👁 1 views

An emerging view is that the purchasing function should be on an equal level of importance in the organization with marketing, human resource management, ®nance and the production/ operations functions. ## * Purchasing is moving away from the traditional adversarial approach between the buyer and

Mutational analysis of the structure and
Mutational analysis of the structure and function of opioid receptors
✍ P. Y. Law; Y. H. Wong; H. H. Loh 📂 Article 📅 1999 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 151 KB 👁 2 views

The cloning of the opioid receptors allows the investigation of receptor domains involved in the peptidic and nonpeptidic ligand interaction and activation of the opioid receptors. Receptor chimera studies and mutational analysis of the primary sequences of the opioid receptors have provided insigh