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Evolution of resistance to penicillin and cephalosporin antibiotics

✍ Scribed by Staffan Normark; Frederik Lindberg

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
675 KB
Volume
3
Category
Article
ISSN
0265-9247

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✦ Synopsis

Bacterial resistance mechanisms to the antibiotics known as p-lactams, which include the penicillins and cephalosporins, can take several forms but frequently involve the production of p-lactamases from either plasrnid-or chromosomallyencoded loci. Gram negative bacteria express a P-lactamase from evolutionarily related chromosomal ampC genes. Genetic analysis of both inducible and constitutively expressed AmpC p-lactamases provide insights into the mechanisms regulating production of the enzyme. Evolutionary relationships between the genes of different species are discussed, as well as the regulatory mechanisms that in both laboratory mutants and clinical isolates lead to overproduction of $-lactamase.

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