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Evolution of protein 3D structures as diffusion in multidimensional conformational space

✍ Scribed by Alexander M. Gutin; Azat Ya. Badretdinov

Publisher
Springer
Year
1994
Tongue
English
Weight
340 KB
Volume
39
Category
Article
ISSN
0022-2844

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✦ Synopsis

A theory of protein spatial-structure evolution in terms of random walks in multidimensional conformational space is proposed. It is shown that the spatial divergence in pairs of homologous proteins depends only on their sequence similarity and is independent of the protein size. X-ray data are reasonably well described in terms of the theory developed.

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