Evolution of prostate cancer gene mutations
β Scribed by Burki, Talha Khan
- Book ID
- 122202125
- Publisher
- The Lancet
- Year
- 2013
- Tongue
- English
- Weight
- 264 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1470-2045
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Prostate cancer is considered to be one of the most hormone-dependent human malignancies. As a key mediator of hormonal response, the androgen receptor (AR) is believed to have an important role in the progression of prostate cancer. Mutations in the coding region of the AR gene have been found in b
## Background: Trka, the high affinity, tyrosine kinase receptor for nerve growth factor (ngf) has been implicated as an oncogene in several neoplasms. in prostate cancer, inhibitors of the ngf/trka signal pathway results in tumor growth inhibition. in contrast, inhibition of this trk pathway in th