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Evolution of motif variants and positional bias of the cyclic-AMP response element

✍ Scribed by Brandon Smith; Hung Fang; Youlian Pan; P Roy Walker; A Fazel Famili; Marianna Sikorska

Book ID
115002356
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
350 KB
Volume
7
Category
Article
ISSN
1471-2148

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## Abstract Acute myeloid leukemia (AML) in adults has a 20% 5‐year disease‐free survival despite treatment with aggressive cytotoxic chemotherapy. Previous work from our laboratory demonstrated that the majority of patients with acute lymphoid and myeloid leukemia overexpress CREB in the bone marr