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Evolution of model proteins on a foldability landscape

✍ Scribed by Sridhar Govindarajan; Richard A. Goldstein

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
75 KB
Volume
29
Category
Article
ISSN
0887-3585

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✦ Synopsis

We model the evolution of simple lattice proteins as a random walk in a fitness landscape, where the fitness represents the ability of the protein to fold. At higher selective pressure, the evolutionary trajectories are confined to neutral networks where the native structure is conserved and the dynamics are non self-averaging and nonexponential. The optimizability of the corresponding native structure has a strong effect on the size of these neutral networks and thus on the nature of the evolutionary process. Proteins

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