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Evolution of microRNAs located within Hox gene clusters

✍ Scribed by Andrea Tanzer; Chris T. Amemiya; Chang-Bae Kim; Peter F. Stadler

Book ID
102890886
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
615 KB
Volume
304B
Category
Article
ISSN
1552-5007

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✦ Synopsis

Abstract

MicroRNAs (miRNAs) form an abundant class of non‐coding RNA genes that have an important function in post‐transcriptional gene regulation and in particular modulate the expression of developmentally important transcription factors including Hox genes. Two families of microRNAs are genomically located in intergenic regions in the Hox clusters of vertebrates. Here we describe their evolution in detail. We show that the micro RNAs closely follow the patterns of protein evolution in the Hox clusters, which is characterized by cluster duplications followed by differential gene loss. J. Exp. Zool. (Mol. Dev. Evol.) 304B: 1–10, 2005. Β© 2005 Wiley‐Liss, Inc.

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