𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

✍ Scribed by Herbert Tilg; Alexander R. Moschen

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
376 KB
Volume
52
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

Whereas in most cases a fatty liver remains free of inflammation, 10%-20% of patients who have fatty liver develop inflammation and fibrosis (nonalcoholic steatohepatitis [NASH]). Inflammation may precede steatosis in certain instances. Therefore, NASH could reflect a disease where inflammation is followed by steatosis. In contrast, NASH subsequent to simple steatosis may be the consequence of a failure of antilipotoxic protection. In both situations, many parallel hits derived from the gut and/or the adipose tissue may promote liver inflammation. Endoplasmic reticulum stress and related signaling networks, (adipo)cytokines, and innate immunity are emerging as central pathways that regulate key features of NASH.

πŸ“œ SIMILAR VOLUMES

Progress in understanding the pathogenes
Progress in understanding the pathogenesis of nonalcoholic fatty liver disease
✍ Richard H. Moseley πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 159 KB πŸ‘ 1 views

The pathogenesis of nonalcoholic steatohepatitis (NASH) is poorly defined. Feeding mice a diet deficient in methionine and choline (MCD diet) induces experimental NASH. Osteopontin (OPN) is a Th1 cytokine that plays an important role in several fibroinflammatory diseases. We examined the role of OPN

Sonographic measurement of the thickness
Sonographic measurement of the thickness of subcutaneous tissues in nonalcoholic fatty liver disease versus other chronic liver diseases
✍ Thomas R. Riley; Michael A. Bruno πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 103 KB πŸ‘ 1 views

## Purpose: To measure an average subcutaneous tissue thickness in nonalcoholic fatty liver disease (nafld) and other liver diseases using bedside sonography and make comparisons of thickness between groups. the study also addressed whether a cut-off subcutaneous tissue thickness exists below which