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Evolution of functional diversity in the cupin superfamily

โœ Scribed by Jim M Dunwell; Alastair Culham; Carol E Carter; Carlos R Sosa-Aguirre; Peter W Goodenough


Book ID
114327166
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
139 KB
Volume
26
Category
Article
ISSN
0968-0004

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Mechanistically diverse enzyme superfami
โœ John A Gerlt; Patricia C Babbitt ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 779 KB

The strategy that nature has used to evolve new catalytic activities from pre-existing enzymes (i.e. retention of substrate binding or of catalytic mechanism) has been controversial. Recent work supports a strategy in which a partial reaction, catalyzed by a progenitor, is retained, and the active-s