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Evidence that γ-secretase mediates oxidative stress-induced β-secretase expression in Alzheimer's disease

✍ Scribed by Dong-Gyu Jo; Thiruma V. Arumugam; Ha-Na Woo; Jong-Sung Park; Sung-Chun Tang; Mohamed Mughal; Dong-Hoon Hyun; Jun-Hyung Park; Yun-Hyung Choi; A-Ryeong Gwon; Simonetta Camandola; Aiwu Cheng; Huaibin Cai; Weihong Song; William R. Markesbery; Mark P. Mattson

Book ID
116781370
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
730 KB
Volume
31
Category
Article
ISSN
0197-4580

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## Abstract Glutathione (GSH) is an important endogenous antioxidant found in millimolar concentrations in the brain. GSH levels have been shown to decrease with aging. Alzheimer's disease (AD) is a neurodegenerative disorder associated with aging and oxidative stress. Aβ(1–42) has been shown to in