Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-κB activation and proliferation in human head and neck squamous cell carcinoma

Constitutive activation of transcription

Constitutive activation of transcription factors NF-κB, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines

✍ Frank G. Ondrey; Gang Dong; John Sunwoo; Zhong Chen; Jeffrey S. Wolf; Caren V. C 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 251 KB 👁 1 views

We previously reported that human head and neck squamous cell carcinomas (HNSCCs) express the proinflammatory and pro-angiogenic cytokines interleukin (IL)-1a, IL-6, IL-8, and granulocyte-macrophage colonystimulating factor in vitro and in vivo. The promoter region of the genes encoding these cytoki