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Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function

✍ Scribed by Mariella Della Chiesa; Elisa Romeo; Michela Falco; Mirna Balsamo; Raffaella Augugliaro; Lorenzo Moretta; Cristina Bottino; Alessandro Moretta; Massimo Vitale

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
251 KB
Volume
38
Category
Article
ISSN
0014-2980

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✍ Cristina Bottino; Michela Falco; Simona Sivori; Lorenzo Moretta; Alessandro More 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB 👁 2 views

P50/KIR2DS molecules represent the activating form of the HLA-C-specific inhibitory NK receptors. They are characterized, in the transmembrane portion, by a charged amino acid that is involved in coupling with signal-transducing adaptor polypeptides. In this study we identified a novel p50.2/KIR2DS2