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Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

✍ Scribed by Hong Chen; Olga Charlat; Louis A Tartaglia; Elizabeth A Woolf; Xun Weng; Stephen J Ellis; Nathan D Lakey; Janice Culpepper; Karen J More; Roger E Breitbart; Geoffrey M Duyk; Robert I Tepper; Jay P Morgenstern

Book ID
117268142
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
98 KB
Volume
84
Category
Article
ISSN
0092-8674

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## Abstract Leptin is elevated in obesity and has been suggested to increase the risk of colorectal cancer (CRC), although the evidence is conflicting. The objective of this study was to compare the susceptibility to colon carcinogenesis of __db__/__db__ mice that have highly elevated circulating l