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Evidence that Meiotic Sex Chromosome Inactivation Is Essential for Male Fertility

✍ Scribed by Hélène Royo; Grzegorz Polikiewicz; Shantha K. Mahadevaiah; Haydn Prosser; Mike Mitchell; Allan Bradley; Dirk G. de Rooij; Paul S. Burgoyne; James M.A. Turner

Book ID
113563212
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
979 KB
Volume
20
Category
Article
ISSN
0960-9822

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Fertile male mice with three sex chromos
Fertile male mice with three sex chromosomes: Evidence that infertility in XYY male mice is an effect of two Y chromosomes
✍ Patricia A. Hunt; Eva M. Eicher 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 1008 KB

In the mouse XYY males are sterile, presumably because pairing abnormalities resulting from the presence of three sex chromosomes lead to meiotic breakdown. We have produced male mice, designated XYY\*X, that have three sex chromosomes pairing regions but only one intact Y chromosome. Unexpectedly X