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Evidence that Hyperprolinemia Alters Glutamatergic Homeostasis in Rat Brain: Neuroprotector Effect of Guanosine

✍ Scribed by Andréa G. K. Ferreira; Aline A. da Cunha; Emilene B. Scherer; Fernanda R. Machado; Maira J. da Cunha; Andressa Braga; Ben Hur Mussulini; Júlia D. Moreira; Susana Wofchuk; Diogo O. Souza; Angela T. S. Wyse

Publisher: Springer
Year: 2011
Tongue: English
Weight: 396 KB
Volume: 37
Category: Article
ISSN: 0364-3190
DOI: 10.1007/s11064-011-0604-1

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## Abstract Patients affected by peroxisomal disorders commonly present neurologic dysfunction and brain abnormalities, whose neuropathology is poorly understood. Given that high sustained concentrations of pristanic acid (Prist) are found in the brain of these patients, it is conceivable that this