Evidence that blockade of post-synaptic 5-HT1receptors elicits feeding in satiated rats

✍ Scribed by C. T. Dourish; M. L. Clark; A. Fletcher; S. D. Iversen

• Book ID: 104776439
• Publisher: Springer
• Year: 1989
• Tongue: English
• Weight: 567 KB
• Volume: 97
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00443413

✦ Synopsis

The effects of nine central 5-HT antagonists on food intake in free feeding male rats were examined. The 5-HT2 antagonists ritanserin and ketanserin and the selective 5-HT 3 antagonists ICS 205-930 and MDL 72222 had no effect on food intake. In contrast, the non-selective 5-HT antagonists metergoline, methiothepin, mesulergine, mianserin and methysergide (all of which have high affinity for various 5-HT1 receptor subtypes), dose-dependently increased food intake during a 4-h daytime test. Furthermore, metergoline dose dependently increased food intake over a 24-h period. Suprisingly, mesulergine decreased food intake over a 24-h period at the same doses that increased daytime food intake. This may indicate that the increase in daytime feeding produced by mesulergine is a non-specific response. Although the antagonists used have varying degrees of selectivity for 5-HT receptor subtypes, the pattern of results suggests that postsynaptic 5-HT1 receptors (possibly of the 5-HTlc type) play an important role in the control of feeding in rats.