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Evidence that 2-methylacetoacetate induces oxidative stress in rat brain

✍ Scribed by Guilhian Leipnitz; Bianca Seminotti; Alexandre U. Amaral; Carolina G. Fernandes; Carlos S. Dutra-Filho; Moacir Wajner

Publisher: Springer
Year: 2010
Tongue: English
Weight: 170 KB
Volume: 25
Category: Article
ISSN: 0885-7490
DOI: 10.1007/s11011-010-9204-z

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## Abstract L‐2‐hydroxyglutaric acid (LGA) is the biochemical hallmark of L‐2‐hydroxyglutaric aciduria (L‐OHGA), an inherited neurometabolic disorder characterized by progressive neurodegeneration with cerebellar and pyramidal signs, mental deterioration, epilepsy, and subcortical leukoencephalopat