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Evidence of Viral Replication in Circulating Dendritic Cells during Hepatitis C Virus Infection

✍ Scribed by Goutagny, Nadège; Fatmi, Ahmed; Ledinghen, Victor De; Penin, François; Couzigou, Patrice; Inchauspé, Geneviève; Bain, Christine

Book ID
118030357
Publisher
University of Chicago Press
Year
2003
Tongue
English
Weight
121 KB
Volume
187
Category
Article
ISSN
0022-1899

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Chronic evolution of acute hepatitis C (aHC) occurs in more than 80% of patients but can frequently be prevented by early treatment with interferon (IFN)-alpha. Plasmacytoid dendritic cells (pDCs) are the major endogenous IFN-alpha producers, but their role in aHC is unknown. In this study, frequenc