Evidence of selective interaction between adenosine deaminase and acid phosphatase polymorphisms in fetuses carried by diabetic women
✍ Scribed by E. Bottini; G. Gerlini; N. Lucarini; A. Amante; F. Gloria-Bottini
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 163 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
Possible selective interaction between genetic polymorphisms of acid phosphatase locus 1 (ACP1) and adenosine deaminase (ADA) has been investigated in a sample of 211 infants from diabetic women, and in 350 consecutive infants from normal women. Newborns from diabetic pregnancies carrying the ADA 2 allele show a lower proportion of BA and CB phenotypes (heterozygotes for the main allele of ACP1 system), compared with both their mothers and normal infants. The observation suggests that, in a diabetic environment, intrauterine selection may act against double heterozygotes for the ACP1 and ADA systems.