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Evidence of Hypoxia-Inducible Factor-1 in Vascular Endothelial and Smooth Muscle Cells

✍ Scribed by John F. Schmedtje; Jr.; W.L. Liu; Yanshan Ji; Tonya M. Thompson; Marschall S. Runge


Book ID
115578226
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
137 KB
Volume
220
Category
Article
ISSN
0006-291X

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## Abstract Hypoxia promotes angiogenesis by modulating the transcriptional regulator hypoxia‐inducible factor 1Ξ± (HIF‐1Ξ±). HIF‐1Ξ± is a master regulator of the hypoxic response, and its proangiogenic activities include, but are not limited to, regulation of vascular endothelial growth factor (VEGF)