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Evidence of apoptosis and mitochondrial abnormalities in peripheral blood cells of Huntington’s disease patients

✍ Scribed by Sandra Almeida; Ana Bela Sarmento-Ribeiro; Cristina Januário; A Cristina Rego; Catarina R Oliveira

Book ID
116297111
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
246 KB
Volume
374
Category
Article
ISSN
0006-291X

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## Abstract Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion in the __IT‐15__ gene; however, it remains unknown how the mutation leads to selective neurodegeneration. Several lines of evidence suggest impaired mitochondrial f