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Evidence of a role for protein kinase C in epidermal growth factor-induced prostaglandin E2 synthesis in amnion cells

✍ Scribed by DA Kniss; J Mershon; H-C Su; J Sonek; RH Fertel; M Waxman; JD Iams; SG Gabbe


Book ID
118890428
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
137 KB
Volume
36
Category
Article
ISSN
0020-7292

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## Abstract Epidermal growth factor (EGF), which stimulates tyrosine‐specific protein kinase activity both in vivo and in vitro, inhibits proliferation of A431 human epidermoid carcinoma cells. After mutagenesis clonal cell lines that were resistant to the growth inhibitory effects of EGF were sele