✦ LIBER ✦

Evidence of a common site of action for the antitumor agents, hydroxyurea and guanazole

✍ Scribed by J. A. Wright; W. H. Lewis

Publisher: John Wiley and Sons
Year: 1974
Tongue: English
Weight: 274 KB
Volume: 83
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040830314

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✦ Synopsis

Abstract

Hydroxyurea and guanazole were used as selective agents in tissue culture to obtain independent Chinese hamster ovary cell lines resistant to the cytotoxic effects of hydroxyurea or guanazole. In all cases tested a cell line selected for resistance to one of the antitumor agents exhibited resistance to both drugs. This result supports the view that these two drugs act at a common site.

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