Evidence from Circular Dichroism and from Melting Behavior for Helix-Inducing Complexation of a Designed β3-Pentadecapeptide with DNA Duplexes. Preliminary Communication
✍ Scribed by Thierry Kimmerlin; Kenji Namoto; Dieter Seebach
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- German
- Weight
- 152 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Inspired by naturally occurring DNA‐binding proteins and their artificial α‐peptidic mimics reported to date, a research project was initiated aiming at creating a new class of β‐peptides capable of binding to and ultimately regulating the functions of DNA. As an initial foray, a β^3^‐pentadecapeptide 1, which bears H‐bonding Asn side chains and positively charged Lys side chains, was designed and synthesized on the solid support. DNA‐Complexation studies by means of circular dichroism and DNA‐melting‐temperature measurements revealed the first preliminary indications that support the existence of ordered interactions between β‐peptides and DNA.