## Abstract Previous work by Grob et al. [__Lancet__ i:774, 1987] has demonstrated that allogeneic, Tβcellβdepleted bone marrow transplant recipients have a better prognosis for reactivated cytomegalovirus (CMV) infection if their donor is also immune. It was proposed that adoptively transferred hu
Evidence for transfer of cellular and humoral immunity to cytomegalovirus from donor to recipient in allogeneic bone marrow transplantation
β Scribed by G. J. BOLAND; A. M. VLIEGER; C. VERVERS; G. C. De GAST
- Book ID
- 108698404
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 541 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0009-9104
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The reconstitution of the human cytomegalovir u s (CMV) antibody response in CMV seropositive bone marrow transplant patients was investigated by comparing 11 patients whose donors were CMV seropositive with 8 whose donors were C M V seronegative. Evidence for primary or secondary responses to C M V
Recipients of allogeneic bone marrow transplantation are immunosuppressed as a result of their primary disease and by myeloablative therapy. Such patients are dependent on multiple blood products and are at risk for hepatitis B v i r u s infection. Active immunization against hepatitis B in the imme