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Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A

✍ Scribed by Takahiro Hatanaka; Wei Huang; Ruan Ling; Puttur D Prasad; Mitsuru Sugawara; Frederick H Leibach; Vadivel Ganapathy


Book ID
117047787
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
293 KB
Volume
1510
Category
Article
ISSN
0005-2736

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We studied the long-terms effects of interleukin-1beta (IL-1beta; 3 to 6 h) on alpha-(methylamino) isobutyric acid (MeAIB), a nonmetabolizable amino acid transported by system A. We found that IL-1beta induced a large decrease in MeAIB uptake by human osteoarthritic synovial cells and a concomitant