## Abstract The role of water in the proton transfer mechanism between the carboxylic and the amino group in tryptophan was studied through the direct, intramolecular reaction in presence of a continuum and the single water molecule mediated, intermolecular reaction in vacuum and in presence of a c
Evidence for the role of ammonia in the intracerebral transfer and metabolism of tryptophan
✍ Scribed by Dr. Patrick Grippon; Monique le Poncin Lafitte; Michèle Boschat; Shwen Wang; Grazyna Faure; Dominique Dutertre; Pierre Opolon
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 454 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
After portacaval shunt in the rat, the transport of tryptophan and other neutral amino acids across the blood-brain barrier is enhanced. To determine the role of NH, in the intracerebral transfer of tryptophan and serotonin metabolism, solutions containing either saline
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In a previous study, we characterized two tryptophan hydroxylase mRNAs (TPH mRNAs) in the pineal gland. However, we failed to detect these species in the raphe by Northern blot experiments. Here, we report by S1 nuclease analysis and in situ hybridization that these two TPH mRNAs, as well as a third