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Evidence for the Presence of the Second Allele of the Neurofibromatosis Type 1 Gene in Melanocytes Derived from Café au Lait Macules of NF1 Patients

✍ Scribed by Ingrid Eisenbarth; Günter Assum; Dieter Kaufmann; Winfrid Krone


Book ID
115580678
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
70 KB
Volume
237
Category
Article
ISSN
0006-291X

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✍ Ingrid Eisenbarth; Sven Hoffmeyer; Dieter Kaufmann; Günter Assum; Winfrid Krone 📂 Article 📅 1995 🏛 Springer-Verlag 🌐 English ⚖ 889 KB

Neurofibromatosis type 1 (NF1) is characterized by clinical features that primarily affect tissues derived from the neural crest (neurofibromas, caf~-aulait macules). Because aberrant regulation of alternative splicing in the NF1 gene transcript may be of functional significance, cultured melanocyte