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Evidence for the possible formation of a toxic tyrosine metabolite by the liver microsomal drug metabolizing system

โœ Scribed by J. C. David


Book ID
112349097
Publisher
Springer-Verlag
Year
1976
Tongue
English
Weight
798 KB
Volume
292
Category
Article
ISSN
0028-1298

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Large differences in induced cellular toxicity were observed in the presence or absence of a rat liver micro-soma1 metabolizing system (S-9) during drug testing in the mouse lymphoma assay. After studying the fate of three drugs in this test system, several mechanisms were demonstrated whereby S-9 r