Evidence for the molecular heterogeneity of sickle cell anemia chromosomes bearing the βS/Benin haplotype

✍ Scribed by George P. Patrinos; Piera Samperi; Luca lo Nigro; Panagoula Kollia; Gino Schiliro; Manoussos N. Papadakis

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 55 KB
• Volume: 80
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.20400

✦ Synopsis

Abstract

There are at least four distinct African and one Asian chromosomal backgrounds (haplotypes) on which the sickle cell mutation has arisen. Additionally, previous data suggest that the β^S^/Bantu haplotype is heterogeneous at the molecular level. Here, we report the presence of the ^A^γ −499 T→A variation in sickle cell anemia chromosomes of Sicilian and North African origin bearing the β^S^/Benin haplotype. Being absent from North American β^S^/Benin chromosomes, which were studied previously, this variation is indicative for the molecular heterogeneity of the β^S^/Benin haplotype. Am. J. Hematol. 80:79–80, 2005. © 2005 Wiley‐Liss, Inc.