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Evidence for the involvement of a T-cell-associated serine proteinase (TSP-1) in cell killing

โœ Scribed by Simon, M.M.; Fruth, U.; Simon, H.G.; Kramer, M.D.

Book ID
122679835
Publisher
Elsevier Science
Year
1987
Weight
876 KB
Volume
138
Category
Article
ISSN
0769-2625

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An inhibitor specific for the mouse T-cell associated serine proteinase 1 (TSP-1) inhibits the cytolytic potential of cytoplasmic granules but not of intact cytolytic T cells
โœ Markus M. Simon; Marlot Prester; Michael D. Kramer; Uli Fruth ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 740 KB

We have investigated a proteinase inhibitor, designed according to the preferred amino acid sequence that is cleaved by the murine T-cell specific serine proteinase 1 (TSP-1) for its effect on the cytolytic potential of cloned cytotoxic T-cell lines (CTLL) and of cytoplasmic granules, derived from t