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Evidence for the Existence of an α1(V)α2(V)α3(V) Collagen Molecule in Human Placental Tissue

✍ Scribed by R. Kent Rhodes; Edward J. Miller


Book ID
114178929
Publisher
Elsevier
Year
1981
Weight
571 KB
Volume
1
Category
Article
ISSN
0174-173X

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Osteogenesis imperfecta (OI) is a congenital disease of connective tissue, most often caused by single amino acid substitutions of glycine residues within the triple helical region of collagen I. Collagen I consists of two alpha 1 chains and one alpha 2 chain. Thus, a substitution in the alpha 1(I)