Evidence for the existence of a family of bacterial nitroreductases capable of activating nitrated polycyclics to mutagens
✍ Scribed by McCoy, Elena C. ;Rosenkranz, Herbert S. ;Mermelstein, Robert
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1981
- Weight
- 357 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0192-2521
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✦ Synopsis
Abstract
A derivative of Salmonella typhimurium TA98 which does not respond to the potent mutagenicity of 1,8‐dinitropyrene is described. This novel strain also shows a lack of response to the mutagenic action of 1,3‐dinitropyrene and a greatly reduced response to 1,6‐dinitropyrene and 1‐nitropyrene. The responses to 1,3,6‐trinitropyrene and 1,3,6,8‐tetranitropyrene are affected to a much lesser extent. This strain (TA98/1,8DNP~6~) is fully sensitive to the mutagenicity of 4‐nitroquinoline‐1‐oxide, niridazole, nitroacridine, and nonnitrated frameshift mutagens. This strain appears to be deficient in a nitroreductase which reduces nitrated pyrenes and possibly other nitrated polycyclic aromatic hydrocarbons to corresponding hydroxylamines, the penultimate mutagens.