Evidence for the evolutionary significance of developmental variation in an abundant protein of orthopteran muscle

ENIGMA—Evidence-based network for the in

ENIGMA—Evidence-based network for the interpretation of germline mutant alleles: An international initiative to evaluate risk and clinical significance associated with sequence variation in BRCA1 and BRCA2 genes

✍ Amanda B. Spurdle; Sue Healey; Andrew Devereau; Frans B. L. Hogervorst; Alvaro N 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB 👁 2 views

As genetic testing for predisposition to human diseases has become an increasingly common practice in medicine, the need for clear interpretation of the test results is apparent. However, for many disease genes, including the breast cancer susceptibility genes BRCA1 and BRCA2, a significant fraction