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Evidence for the binding affinity of daunomycin to HMGB1 protein in chromatin and in solution

✍ Scribed by Safa Lotfi; Azra Rabbani-Chadegani; Parinaz Ghadam

Book ID: 119261197
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 639 KB
Volume: 52
Category: Article
ISSN: 0141-8130
DOI: 10.1016/j.ijbiomac.2012.09.024

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## Abstract Understanding of cell regulation is limited by our inability to measure molecular binding rates for proteins within the structural context of living cells, and many systems biology models are hindered because they use values obtained with molecules binding in solution. Here, we present