Evidence for T cell receptor-HLA class II molecule interaction in the response to superantigenic bacterial toxins
✍ Scribed by Bernhard Fleischer; Hans-Willi Mittrücker
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 280 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
The staphylococcal enterotoxins and related microbial Tcell mitogens stimulateT cells by cross-linking variable parts of theTcell receptor (TcR) with MHC class I1 molecules on accessory or target cells. In this report we describe that a given combination of T cell, accessory cell (AC) and toxin can be non-stimulatory. However, the same Tcell can respond to the same toxin on another AC and the same AC can present the same toxin to another Tcell. This indicates that in the complex formed betweenTcR, toxin and class I1 molecule an interaction between TcR and class I1 molecule takes place.
* Supported by the BMFT.