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Evidence for separate Na+, K+, Cl− and K+, Cl− co-transport systems in mouse pancreatic β-cells

✍ Scribed by Per-Erik Sandström; Janove Sehlin


Book ID
115888948
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
254 KB
Volume
238
Category
Article
ISSN
0014-2999

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We have investigated the presence of Na-K-Cl cotransport in alveolar type II cells using uptake of 86Rb. Several data support the presence of a Na-K-Cl cotransport in these cells. First, a large fraction of ouabain-resistant 86Rb uptake was inhibited by bumetanide and furosemide. Second, bumetanide-