Cytogenetic analyses have shown that aberrations involving 12q13-15 are frequent chromosomal changes in a variety of human benign mesenchymal tumors, e.g., pleomorphic adenomas of the parotid gland, pulmonary chondroid hamartomas, lipomas, and uterine leiomyomas. Recently, the high-mobility group pr
Evidence for RAD51L1/HMGIC fusion in the pathogenesis of uterine leiomyoma
โ Scribed by Tomoko Takahashi; Nobutaka Nagai; Hiromune Oda; Koso Ohama; Nanao Kamada; Kiyoshi Miyagawa
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 156 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1045-2257
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## Abstract Eker rats carry a defect in the __Tscโ2__ tumor suppressor gene and female Eker rats develop uterine leiomyoma with a high frequency. The presentation, response to hormones and molecular alterations in these mesenchymal smooth muscle tumors, closely resembles their cognate human disease
## Abstract An overexpression of __HMGA2__ is supposed to be a key event in the genesis of leiomyoma with chromosomal rearrangements affecting the region 12q14โ15 targeting the __HMGA2__ gene, but gene expression data regarding differences between uterine leiomyomas with and those without 12q14โ15