Evidence for pre and postsynaptic nigrostriatal dysfunction in the fragile X tremor–Ataxia syndrome
✍ Scribed by Daniel G. Healy; Susan Bressman; John Dickson; Laura Silveira-Moriyama; Susanne A. Schneider; Sean S.O. Sullivan; Luke Massey; Kailash P. Bhatia; Karen Shaw; Kailash P. Bhatia; Jamshed Bomanji; Nicholas W. Wood; Andrew J. Lees
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 387 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0885-3185
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The expansion of the trinucleotide repeat (CGG)n in successive generations through maternal meiosis is the cause of fragile X syndrome. Analysis of CA repeat polymorphisms flanking the FMR-1 gene provides evidence of a limited number of "founder" chromosomes and predisposing high-risk haplotypes rel