✦ LIBER ✦

Evidence for neurological dysfunction in end-stage protoporphyric liver disease

✍ Scribed by Jeffrey M. Rank; Robert Carithers; Joseph Bloomer

Book ID: 102853535
Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 723 KB
Volume: 18
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840180619

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✦ Synopsis

Protoporphyria is a genetic disorder characterized by a defect in the enzyme ferrochelatase, which catalyzes the chelation of iron to protoporphyrin. This causes excessive accumulation and excretion of protoporphyrin. The predominant clinical feature is photosensitivity. Progressive and fatal liver disease occurs in a small percentage of cases. We report our experience with eight patients with end-stage protoporphyric liver disease in whom a syndrome developed before transplantation that resembled the neurological crises of the acute porphyrias. This syndrome was characterized by abdominal pain, hypertension, tachycardia, extremity pain and weakness, constipation and nausea and vomiting. Erythrocyte and serum protoporphyrin levels were markedly increased in all patients. In one patient, profound hemolysis developed during the anhepatic phase of transplantation and continued over a period of 72 hr, causing an extreme increase in the serum protoporphyrin level. Progressive weakness deteriorated to paralysis in this patient. This phenomenon suggests that protoporphyrin may gain access to neural tissue when serum levels are markedly increased, causing neurotoxicity. (HEPATOLOGY 1993;

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