Evidence for intermediates and a change in rate-limiting step in the aminolysis of the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine by cyclic amines
โ Scribed by Wichems, Desmond N.; Nag, Shimona; Mills, Jane; Fishbein, James C.
- Book ID
- 127266243
- Publisher
- American Chemical Society
- Year
- 1992
- Tongue
- English
- Weight
- 780 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0002-7863
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
We previously suggested that hydroxyl free radical (โขOH) production may play a role in carcinogenesis induced by N-methyl-Nะ-nitro-N-nitrosoguanidine (MNNG). MNNGinduced gastric cancer in rats and human gastric carcinoma occur most often in the antral mucosa and rarely in the normal fundic mucosa. W
## Abstract Kinetic data are reported for the waterโcatalyzed hydrolysis of several (arylsulfonyl)โmethyl perchlorates in water and for the HMPAโcatalyzed decomposition of the same substrates in dichloromethane. Under both conditions, the reaction exhibits general base catalysis and the covalent pe