✦ LIBER ✦

Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an american indian population

✍ Scribed by Long, Jeffrey C.; Knowler, William C.; Hanson, Robert L.; Robin, Robert W.; Urbanek, Margrit; Moore, Elisa; Bennett, Peter H.; Goldman, David

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 35 KB
Volume: 81
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19980508)81:3<216::aid-ajmg2>3.0.co;2-u

No coin nor oath required. For personal study only.

✦ Synopsis

To identify specific genes affecting vulnerability or resistance, we performed a whole-autosomal genome scan for genetic linkage to alcohol dependence in a Southwestern American Indian tribe. Genotypes at 517 autosomal microsatellite loci and clinical evaluations were available for 152 subjects belonging to extended pedigrees and forming 172 sib-pairs. Highly suggestive evidence for linkage emerged for two genomic regions using two- and multipoint sib-pair regression methods; both regions harbored neurogenetic candidate genes. The best evidence is seen with D11S1984 (nominal P = 0.00007, lod approximately equal to 3.1) on chromosome 11p, in close proximity to the DRD4 dopamine receptor and tyrosine hydroxylase (TH) genes. Good evidence is seen with D4S3242 (nominal P = 0.0002, lod approximately equal to 2.8) on chromosome 4p, near the beta1 GABA receptor gene. Interestingly, three loci in the alcohol dehydrogenase gene cluster on chromosome 4q showed evidence for linkage with two-point analyses, but not multipoint analysis.

📜 SIMILAR VOLUMES

An autosomal genomic screen for autism

✍ Faraone, Stephen V.; Meyer, Joanne; Matise, Tara; Svrakic, Dragun; Pepple, John; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 47 KB 👁 2 views

Autism is a severe neurodevelopmental disorder defined by social and communication deficits and ritualistic-repetitive behaviors that are detectable in early childhood. The etiology of idiopathic autism is strongly genetic, and oligogenic transmission is likely. The first stage of a two-stage genomi

An Overture to an Indian Wedding

✍ Madan Achar 📂 Fiction 📅 2019 🌐 English ⚖ 21 KB 👁 2 views

Genome-wide search for genes affecting t

Genome-wide search for genes affecting the risk for alcohol dependence

✍ Reich, Theodore; Edenberg, Howard J.; Goate, Alison; Williams, Jeff T.; Rice, Jo 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 46 KB 👁 2 views

Alcohol dependence is a leading cause of morbidity and premature death. Several lines of evidence suggest a substantial genetic component to the risk for alcoholism: sibs of alcoholic probands have a 3-8 fold increased risk of also developing alcoholism, and twin heritability estimates of 50-60% are

Evidence for linkage to psychosis and ce

Evidence for linkage to psychosis and cerebral asymmetry (relative hand skill) on the X chromosome

✍ Laval, S.H.; Dann, J.C.; Butler, R.J.; Loftus, J.; Rue, J.; Leask, S.J.; Bass, N 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 41 KB 👁 2 views

The hypothesis that psychosis arises as a part of the genetic diversity associated with the evolution of language generates the prediction that illness will be linked to a gene determining cerebral asymmetry, which, from the evidence of sex chromosome aneuploidies, is present in homologous form on t

Clinical and genetic study of Friedreich

Clinical and genetic study of Friedreich ataxia in an Australian population

✍ Delatycki, Martin B.; Paris, Damien B.B.P.; Gardner, R.J. McKinlay; Nicholson, G 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 47 KB 👁 2 views

Friedreich ataxia is an autosomal recessive disorder caused by mutations in the FRDA gene that encodes a 210-amino acid protein called frataxin. An expansion of a GAA trinucleotide repeat in intron 1 of the gene is present in more than 95% of mutant alleles. Of the 83 people we studied who have muta

Human chromosomes 11p15 and 4p12 and alc

Human chromosomes 11p15 and 4p12 and alcohol dependence: Possible association with theGABRB1 gene

✍ Parsian, Abbas; Zhang, Zhen Hua 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 21 KB 👁 1 views

To determine the role of genes in the chromosomal regions 11p15 and 4p12 in the development of alcohol dependence, a sample of alcoholics (n = 133) and normal controls (n = 89) were screened using polymorphisms in the dopamine D4 receptor (DRD4), tyrosine hydroxylase (TH), and GABA receptor ␤1 (GABR