✦ LIBER ✦

Evidence for GABAergic inhibitory deficits in major depressive disorder

✍ Scribed by Paul E. Croarkin; Andrea J. Levinson; Zafiris J. Daskalakis

Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 268 KB
Volume: 35
Category: Article
ISSN: 0149-7634
DOI: 10.1016/j.neubiorev.2010.10.002

No coin nor oath required. For personal study only.

✦ Synopsis

Converging evidence suggests that deficits in gamma-aminobutyric acid (GABA) functioning are implicated in the pathophysiology of major depressive disorder (MDD). This is highlighted by research investigating cortical inhibition (CI), a process whereby GABAergic interneurons selectively attenuate pyramidal neurons. Transcranial magnetic stimulation (TMS) paradigms evaluate this marker of neuronal inhibitory activity in the cortex. This review will examine the neuroanatomic and neurophysiological evidence from neuroimaging, molecular, treatment, and TMS studies linking dysfunctional GABAergic neurotransmission to MDD.

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