Evidence for complete mutational inactivation of the E-cadherin gene and loss of the wildtype protein in invasive lobular breast carcinoma
✍ Scribed by I. Becker; K.F. Becker; C. Schott; H. Höfler
- Book ID
- 114136484
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 78 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0165-4608
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The cell-cell adhesion receptor gene E-cadherin (CDH1) is expressed by epithelial cells, in which it mediates adhesion and morphogenesis. Invasive lobular carcinoma (ILC) characteristically infiltrates diffusely as single cells; by immunohistochemistry, many of these tumours lack E-cadherin expressi
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