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Evidence for cell-mediated autoimmunity in patients with pemphigus vulgaris and bullous pemphigoid

✍ Scribed by János Hunyadi; Attila Dobozy; Anna Sz. Kenderessy

Publisher
Springer-Verlag
Year
1979
Tongue
English
Weight
313 KB
Volume
265
Category
Article
ISSN
0340-3696

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✦ Synopsis

Lymphoid cells from 4 of 5 patients diagnosed as pemphigus vulgaris (PV) and 6 of 7 patients diagnosed as bullous pemphigoid (BP) demonstrated specific cell-mediated immunity by the production of migration inhibitory factor (MIF) in the presence of autotogous epidermal saline extracts. Clinical treatment of these patients with immunosuppressive agents resulted in a state of unresponsivenes of their lymphoid cells to similar concentrations of the antigen. Controls consisted of lymphoid cells from patients with bullous burns or various drug allergies which failed to show significant MIF production in the presence of autologous skin extract. These studies suggest that both PV and BP patients posses cell-mediated immunity (CMI) to their own autologous tissue antigens and this CMI may play a role in the pathogenesis of these diseases.

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