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Evidence for CCl/CBr⋅⋅⋅π Interactions as an Important Contribution to Protein–Ligand Binding Affinity

✍ Scribed by Hans Matter; Marc Nazaré; Stefan Güssregen; David W. Will; Herman Schreuder; Armin Bauer; Matthias Urmann; Kurt Ritter; Michael Wagner; Volkmar Wehner

Book ID
102724477
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
719 KB
Volume
121
Category
Article
ISSN
0044-8249

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Evidence for CCl/CBr⋅⋅⋅π Interactions as
Evidence for CCl/CBr⋅⋅⋅π Interactions as an Important Contribution to Protein–Ligand Binding Affinity
✍ Hans Matter; Marc Nazaré; Stefan Güssregen; David W. Will; Herman Schreuder; Arm 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 719 KB

## Abstract **Attractive chlorine**: Noncovalent interactions between chlorine or bromine atoms and aromatic rings in proteins open up a new method for the manipulation of molecular recognition. Substitution at distinct positions of two factor Xa inhibitors improves the free energy of binding by in